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Anti-IL4 × Anti-IL13 Bispecific Antibody (TAND-L033)

Recombinant Anti-IL4 × Anti-IL13 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of inhibiting signaling of their cognate cytokines and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of allergic asthma and dermatitis.      

Specifications
Targets
IL4 & IL13
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
IL4
Host
Human
Target 2
IL13
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Allergic asthma and Dermatitis
Targets
Target 1
IL4
Gene ID
3565
UniProt ID
D4HNR6
Alternative Names
IL4; interleukin 4; BSF1; IL-4; BCGF1; BSF-1; BCGF-1; interleukin-4
Target 2
IL13
Gene ID
3596
UniProt ID
P35225
Alternative Names
IL13; interleukin 13; P600; IL-13; interleukin-13

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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