Recombinant Anti-MET × Anti-ErbB-2 Bispecific Antibody (Triplebody) (CAT#: TRIAB-MZ008)
This bispecific anti-c-Met/anti-Her2 antibody in which the anti-Her2 scFv is fused at the C-terminus of the anti-c-Met antibody. It is capable of suppressing the cancer cell proliferation by inhibiting Her2 and c-Met activation as well as increasing anticancer effects by the internalization of c-Met and Her2 into the cells at the same time.
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Specifications
- Target
- MET & ErbB-2
- Type
- Triplebody
- Species Reactivity
- Human
- Target 1
- MET
- Host Species 1
- Human
- Target 2
- ErbB-2
- Host Species 2
- Human
- Application
- WB, Confocal
- Related Disease
- Lung cancer, esophagus cancer and stomach cancer
Target
- Target 1
- MET
- Gene ID
- 4233
- UniProt ID
- A0A024R759
- Alternative Names
- MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase
- Target 2
- ErbB-2
- Gene ID
- 2064
- UniProt ID
- P04626
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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