Recombinant Anti-MET × Anti-ErbB-2 Bispecific Antibody (Triplebody) (CAT#: TRIAB-MZ008)
This bispecific anti-c-Met/anti-Her2 antibody in which the anti-Her2 scFv is fused at the C-terminus of the anti-c-Met antibody. It is capable of suppressing the cancer cell proliferation by inhibiting Her2 and c-Met activation as well as increasing anticancer effects by the internalization of c-Met and Her2 into the cells at the same time.
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Specifications
- Target
- MET & ErbB-2
- Type
- Triplebody
- Species Reactivity
- Human
- Target 1
- MET
- Host Species 1
- Human
- Target 2
- ErbB-2
- Host Species 2
- Human
- Application
- WB, Confocal
- Related Disease
- Lung cancer, esophagus cancer and stomach cancer
Target
- Target 1
- MET
- Gene ID
- 4233
- UniProt ID
- A0A024R759
- Alternative Names
- MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase
- Target 2
- ErbB-2
- Gene ID
- 2064
- UniProt ID
- P04626
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;
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For Research Use Only. Not For Clinical Use.
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