Recombinant Anti-Melanoma-associated proteoglycan × Anti-CD28 Bispecific Antibody (Tandem Diabody) (CAT#: TAND-L047)

Recombinant Anti-melanoma-associated proteoglycan × Anti-CD28 Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. Tandem Diabodies do not carry Fc domains, are smaller than whole IgGs or IgG-derived bsAbs, but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This BsAb can induce a TCR/CD3 independent, "supraagonistic" stimulation of the CD28 molecule on resting human T cells, which depends on tumor cell binding and results in tumor cell killing. It was designed for the treatment of melanoma cancer.


Specific Inquiry
  • Size:
  • Conjugation:
  • Datasheet
  • MSDS
  • COA

Specifications

  • Target
  • Melanoma-associated proteoglycan & CD28
  • Type
  • Tandem Diabody
  • Species Reactivity
  • Human
  • Target 1
  • Melanoma-associated proteoglycan
  • Host Species 1
  • Mouse
  • Target 2
  • CD28
  • Host Species 2
  • Mouse
  • Application
  • FuncS, Promising therapeutic agent
  • Related Disease
  • Melanoma cancer

Target

  • Target 1
  • Melanoma-associated proteoglycan
  • Alternative Names
  • NG2; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG
  • Target 2
  • CD28
  • Alternative Names
  • CD28; CD28 molecule; Tp44; T-cell-specific surface glycoprotein CD28; CD28 antigen

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAND-L047. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare