Products

Anti-Myosin × Anti-CD45 Bispecific Antibody (TAND-L035)

Recombinant Anti-Myosin× Anti-CD45 Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of inhibiting signaling of their cognate factorrs and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of myocardial infarction.      

Specifications
Targets
Myosin & CD45
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
Myosin
Host
Mouse
Target 2
CD45
Host
Mouse
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Myocardial infarction
Targets
Target 1
Myosin
Gene ID
79784
UniProt ID
Q7Z406
Alternative Names
Myosin; ATP-dependent motor proteins
Target 2
CD45
Gene ID
5788
UniProt ID
P08575
Alternative Names
LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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