Recombinant Anti-Pgp × Anti-CD3 Bispecific Antibody (DART) (CAT#: DART-L006)

Recombinant Anti-Pgp × Anti-CD3 Bispecific Antibody (DART) is a diabody-like entity that the VH of the first variable region is linked to the VL of the second binderto stablly generate a DART. This BsAb is capable of targeting the tumor and recruiting T effector cells via binding to the CD3 subunit of the T cell receptor complex. It was designed for the treatment of leukemia.

Specific Inquiry
  • Size:
  • Conjugation:
  • Datasheet
  • MSDS
  • COA

Specifications

  • Target
  • Pgp & CD3
  • Type
  • DART
  • Expression Host
  • CHO
  • Species Reactivity
  • Human
  • Target 1
  • Pgp
  • Host Species 1
  • Mouse
  • Clone 1
  • PHMA02
  • Target 2
  • CD3
  • Host Species 2
  • Mouse
  • Clone 2
  • OKT3
  • Purity
  • >95% judged by SDS-PAGE under reducing condition
  • Application
  • FuncS, Promising therapeutic agent
  • Related Disease
  • Leukemia

Target

  • Target 1
  • Pgp
  • Alternative Names
  • P-glycoprotein; P-glycoprotein 1; multidrug resistance protein 1; MDR1; ATP-binding cassette sub-family B member 1; MBCB1; cluster of differentiation 243; CD243
  • Target 2
  • CD3
  • Alternative Names
  • CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.


For Research Use Only. Not For Clinical Use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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