Products

Anti-VEGF × Anti-PDGFRβ Bispecific Antibody (TAND-L022)

Recombinant Anti-VEGF × Anti-PDGFRβ Bispecific Antibody (TandAb) is a bispecific fusion protein with four binding sites, two of which bind to tumor cell surface antigens and the other two to the immune cells. TandAbs do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than BiTEs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with BiTEs. This BsAb is capable of inhibiting signaling of their cognate receptors and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of solid tumors and age-related macular degeneration (AMD).      

Specifications
Targets
VEGF & PDGFRβ
Type
TandAb
Expression Host
CHO
Species Reactivity
Human
Target 1
VEGF
Host
Human
Target 2
PDGFRβ
Host
Rat
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FuncS, Promising therapeutic agent
Related Disease
Neovascular disorder, such as cancer, eye disorders, and rheumatoid arthritis.
Targets
Target 1
VEGF
Gene ID
7422
UniProt ID
P15692
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor
Target 2
PDGFRβ
Gene ID
5159
UniProt ID
P09619
Alternative Names
IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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