Recombinant Anti-VEGFR2 × Anti-VEGFR2 Bispecific Antibody (CrossMab)
CAT#: CROSS-L020
Recombinant Anti-VEGFR2 × Anti-VEGFR2 Bispecific Antibody (CrossMab) has been generated by applying the Crossmab format to generate an IgGshaped entity that binds each ligand with one arm. This BsAb is capable of inhibiting signaling of their cognate proangiogenics and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. This BsAb can block VEGFR2(KDR)/VEGF interactions, and inhibit both VEGF-induced activation of the receptor and mitogenesis of human endothelial cells. It was designed for the treatment of various tumors.
Specifications
- Target
- VEGFR2 & VEGFR2
- Type
- CrossMab
- Species Reactivity
- Human
- Target 1
- VEGFR2
- Host Species 1
- Mouse
- Target 2
- VEGFR2
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Various tumors
Target
- Target 1
- VEGFR2
- Gene ID
- 3791
- UniProt ID
- A0A024RD88
- Alternative Names
- KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; kina
- Target 2
- VEGFR2
- Gene ID
- 3791
- UniProt ID
- A0A024RD88
- Alternative Names
- KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; kinase insert domain receptor (a type III receptor tyrosine kinase)
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