Anti-BCMA (clone CA8)-mc-MMAF ADC (CAT#: ADC-318CL)

This ADC product is composed of an anti-BCMA antibody (clone CA8) conjugated via mc linker to MMAF(CA8-mcMMAF). It has demonstrated a response in treatment by a MOA (Mechanism of Action) as microtubule inhibitor.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
RNA Expression

Specifications

  • Antibody Overview
  • Anti-BCMA Antibody, , Chimeric CA8 Antibody
  • Clone
  • CA8
  • Linker
  • Mc (maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linkers
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • MMAF (Monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCM; BCMA; CD269; TNFRSF13A; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein;

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone CA8"

See other products for "TNFRSF17"

Recombinant Antibody

CAT Product Name Application Type
HPAB-0009-DJB Mouse Anti-TNFRSF17 Recombinant Antibody (clone CA8) ELISA, Neut, FC, SPR, ADCC, FuncS Mouse IgG
HPAB-0010-DJB Human Anti-TNFRSF17 Recombinant Antibody (HPAB-0010-DJB) ELISA, Neut, ADCC Humanized IgG
HPAB-0011-DJB Mouse Anti-TNFRSF17 Recombinant Antibody (HPAB-0011-DJB) ELISA, FC, IP Mouse IgG
HPAB-0012-DJB Human Anti-TNFRSF17 Recombinant Antibody (HPAB-0012-DJB) ELISA, FC, FuncS Chimeric (Mouse/Human) IgG
HPAB-0013-DJB Human Anti-TNFRSF17 Recombinant Antibody (HPAB-0013-DJB) ELISA, FC, FuncS Chimeric (Mouse/Human) IgG

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for ADC-318CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare