Anti-LAMP1 (clone huMAb1_3)-N-succinimidyl-4-(2-pyridyldithio)butanoate (SPDB)-DM4 (N2-deacetyl-N2-(4-mercapto-4-methyl-1-oxopentyl) maytansine) ADC

CAT#: ADC-127CL

This ADC product is composed of an anti-LAMP1 antibody (clone huMAb1_3) conjugated via N-succinimidyl-4-(2-pyridyldithio)butanoate (SPDB) linker to DM4 (DM4-SPDB-huMAb1 3). It has demonstrated a response in cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.

Gene Expression
Figure 1 Ihc staining of human urinary bladder Figure 2 IHC staining of human colon Figure 3 Cerebral cortex Figure 4 Liver Figure 5 Pancreas Figure 6 Kidney Figure 7 Testis Figure 8 Lymph node Figure 9 RNA cell line category: Low cell line specificity

Specifications

  • Antibody Overview
  • Anti-LAMP1 Antibody, Humanized huMAb1_3
  • Clone
  • huMAb1_3
  • Linker
  • SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
  • Drug
  • DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

  • Introduction
  • The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • LAMP1; lysosomal-associated membrane protein 1; LAMPA; CD107a; LGP120; lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; lysosome-associated membrane protein 1;
REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
Inquiry
Navs

Customer Review

Submit a review or a question

There are currently no Customer reviews or questions for ADC-127CL. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Article title:
DOI/PubMed URL:
Email:
Name:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "LAMP1"

Select a product category from the dropdown menu below to view related products.

CAT Product Name Application Type
VS-0724-YC849 AbPlus™ Anti-LAMP1 Magnetic Beads (VS-0724-YC849) IP, Protein Purification
CAT Product Name Application Type
VS-1024-XY301 Mouse Anti-NHP LAMP1 Recombinant Antibody (clone H4A3) WB, IHC, FC Mouse IgG1, kappa
CAT Product Name Application Type
VS-0425-YC666 Recombinant Anti-LAMP1 Vesicular Antibody, EV Displayed (VS-0425-YC666) ELISA, FC, Cell-uptake
Specific Inquiry
Go to compare Add to compare

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Go to compare

Go to compare