Denileukin diftitox (CAT#: TP-105CL)

A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.


  • Datasheet
  • MSDS
  • COA

Specifications

  • Classify
  • Protein therapeutics that deliver other compounds or proteins
  • Therapeutic
  • Denileukin diftitox
  • Trade Name
  • Ontak
  • Function
  • Directs the cytocidal action of diphtheria toxin to cells expressing the IL2 receptor
  • Examples of clinical use
  • Persistent or recurrent cutaneous T-cell lymphoma whose malignant cells express the CD25 component of the IL2 receptor

References

  • Synonyms
  • Diphtheria toxin precursor, DT, NAD(+--diphthamide ADP- ribosyltransferase)
  • UniProt
  • P00587
  • Genbank
  • V01536

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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