Drotrecogin alfa (CAT#: TP-052CL)
Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis.
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IHC staining of human fallopian tube
(Immunohistochemical staining of human fallopian tube shows positivity in plasma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5550/ihc_selected.jpg
(Immunohistochemical staining of human fallopian tube shows positivity in plasma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5550/ihc_selected.jpg
Figure 2 Liver
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:
Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5550/16155_A_8_4.jpg
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:
Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5550/16155_A_8_4.jpg
Figure 3 Fallopian tube
(Glandular cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16721/39542_A_7_7.jpg
(Glandular cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16721/39542_A_7_7.jpg
Figure 4 Lymph node
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5550/16155_A_8_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5550/16155_A_8_8.jpg
Figure 5 RNA cell line category: Cell line enriched (Hep G2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115718-PROC/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115718-PROC/subcellular
Specifications
- Classify
- Protein therapeutics augmenting an existing pathway: Haemostasis and thrombosis
- Therapeutic
- Drotrecogin-α (activated protein C)
- Trade Name
- Xigris
- Function
- Antithrombotic (inhibits coagulation factors va and viiia), anti-inflammatory
- Examples of clinical use
- Severe sepsis with a high risk of death
References
- Synonyms
- Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C precursor
- UniProt
- P04070
- Genbank
- M11228
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "PROC"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-804 | Recombinant Anti-sheep PROC Antibody | WB, IF, FuncS | IgG |
| MHH-804 | Recombinant Human Anti-sheep PROC Antibody | FC, IP, FuncS | IgG |
| MOB-0370MZ | Recombinant Mouse Anti-Human Protein C Antibody (clone BIQD-5072) | RIA, WB, ELISA | Mouse antibody |
| MRO-1280-CN | Recombinant Rabbit Anti-PROC Monoclonal Antibody (JM93-61) | WB, IF, IHC | Rabbit IgG |
| MRO-2276-CN | Rabbit Anti-PROC Polyclonal Antibody (MRO-2276-CN) | WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-804-F(E) | Recombinant Anti-sheep PROC Antibody Fab Fragment | FC, ELISA, FuncS | Fab |
| HPAB-0240-YC-F(E) | Mouse Anti-PROC Recombinant Antibody; Fab Fragment (HPAB-0240-YC-F(E)) | ELISA | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-804-S(P) | Recombinant Anti-sheep PROC Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| MHH-804-S(P) | Recombinant Human Anti-sheep PROC Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| HPAB-0240-YC-S(P) | Mouse Anti-PROC Recombinant Antibody; scFv Fragment (HPAB-0240-YC-S(P)) | ELISA | Mouse scFv |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1886CQ | Recombinant Rat Anti-Proc Antibody (9071) | ELISA, Inhib, WB |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2872 | Hi-Affi™ Recombinant Rabbit Anti-PROC Monoclonal Antibody (DS2872AB) | WB | IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for TP-052CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.