Galsulfase (CAT#: TP-020CL)

Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for specific cellular recognition. Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family.


  • Datasheet
  • MSDS
  • COA

Specifications

  • Classify
  • Protein therapeutics replacing a protein that is deficient or abnormal: Metabolic enzyme deficiencies
  • Therapeutic
  • Galsulphase
  • Trade Name
  • Naglazyme
  • Function
  • Cleaves the terminal sulphate from the GAG dermatan sulphate, thereby allowing its digestion and preventing GAG accumulation
  • Examples of clinical use
  • Mucopolysaccharidosis vi

References

  • Synonyms
  • ARSB, Arylsufatase B

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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