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  • PE-H-2Kd/Human Erk2 K136Q (QYIHSANVL) MHC Tetramer

PE-H-2Kd/Human Erk2 K136Q (QYIHSANVL) MHC Tetramer (CAT#: MHC-LC208)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of Erk2 K136Q-derived peptide of QYIHSANVL sequence covering 136-144 and H-2Kd molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79930/1999_H7_3_selected.jpg
Figure 2 IHC staining of human cerebral cortex
Figure 2 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic and nuclear positivity in neuronal and glial cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3995/12643_B_9_5_selected.jpg
Figure 3 IHC staining of human hippocampus
Figure 3 IHC staining of human hippocampus
(Immunohistochemical staining of human hippocampus shows strong cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/21384_B_7_6_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Glial cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Neuronal cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/21384_B_8_5.jpg
Figure 5 Colon
Figure 5 Colon
(Endothelial cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_9_3.jpg
Figure 6 Liver
Figure 6 Liver
(Cholangiocytes
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_7_4.jpg
Figure 7 Pancreas
Figure 7 Pancreas
(Exocrine glandular cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Pancreatic endocrine cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_2_3.jpg
Figure 8 Kidney
Figure 8 Kidney
(Cells in glomeruli
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_9_5.jpg
Figure 9 Testis
Figure 9 Testis
(Cells in seminiferous ducts
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_6_6.jpg
Figure 10 Lymph node
Figure 10 Lymph node
(Germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Non-germinal center cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5700/20815_A_9_8.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (K-562)
Figure 11 RNA cell line category: Cell line enhanced (K-562)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000100030-MAPK1
Figure 11 RNA cell line category: Cell line enhanced (K-562)
Figure 11 RNA cell line category: Cell line enhanced (K-562)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000100030-MAPK1

Specifications

  • Allele
  • H-2Kd
  • Class
  • Class I
  • Antigen
  • Erk2 K136Q
  • Antigen Species
  • Human
  • Peptide
  • QYIHSANVL
  • Range
  • 136-144
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
  • Alternative Names
  • MAPK1; mitogen-activated protein kinase 1; ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK

Related Resources

  • Related Signaling Pathways
  • Related Diseases

Downloads

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Mouse Antibody

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Recombinant Antibody

CAT Product Name Application Type
MOB-0695CT Recombinant Mouse anti-Human MAPK1 Monoclonal antibody (4G9) ELISA, FC, WB
MRO-0547-CN Recombinant Mouse Anti-MAPK1 Monoclonal Antibody (5-D2) WB, IF, IHC, FC Mouse IgG1
MRO-0548-CN Recombinant Rabbit Anti-MAPK1 Monoclonal Antibody (CBACN-218) WB, IF, IHC, IP, FC Rabbit IgG
VS3-CJ844 Mouse Anti-MAPK1 Recombinant Antibody (VS3-CJ844) WB Mouse IgG1, κ
VS3-CJ845 Rabbit Anti-MAPK1 Recombinant Antibody (VS3-CJ845) WB, ICC, IF, IHC, IP, FC Rabbit IgG

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0341MZ Chicken Anti-MAPK1 Polyclonal IgY WB Chicken antibody
BRD-0899MZ Chicken Anti-ERK2 Polyclonal IgY WB Chicken antibody

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC209 APC-H-2Kd/Human Erk2 K136Q (QYIHSANVL) MHC Tetramer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2148 Hi-Affi™ Recombinant Rabbit Anti-MAPK1 Monoclonal Antibody (DS2148AB) WB, IHC-P, ICC, FC, IP IgG
MOR-2155 Hi-Affi™ Recombinant Rabbit Anti-MAPK3; MAPK1 Monoclonal Antibody (DS2155AB) WB, IHC-P, ICC, FC IgG

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