Anti-191P4D12 (clone Ha22-2(2,4)6.1)-vc-MMAE ADC (CAT#: ADC-092CL)
This ADC product is composed of an anti-191P4D12 antibody (clone Ha22-2(2,4)6.1) conjugated via vc linker to MMAE (Ha22-2(2,4)6.1vcMMAE). It has demonstrated a response in 191P4D12-expressing cancers treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specific Inquiry
Specifications
- Antibody Overview
- 191P4D12 MAb Ha22-2(2,4)6.1
- Clone
- Ha22-2(2,4)6.1
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in Colon, Pancreas, Ovarian, Breast, Lung, Bladder cancers.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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