IGF1-PE immunotoxin
CAT#: AGTO-L024E
This immunotoxin was achieved by conjugating/fusing the IGF1 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of breast, prostate, and lung cancers.








Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- IGF1-PE
- Toxin Description
- Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Breast, prostate, and lung cancers
Target
- Alternative Names
- IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE35
- Gene ID
- 3480
- UniProt ID
- P08069
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Related Signaling Pathways
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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PSBL-591 | Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-14); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
PSBL-592 | Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-7); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
HPAB-0210CQ-S(P) | Human Anti-IGF1R Recombinant Antibody (clone 15H12); scFv Fragment | ELISA, FC, Neut | Human scFv |
HPAB-0211CQ-S(P) | Human Anti-IGF1R Recombinant Antibody (clone 1H3); scFv Fragment | ELISA, FC, Neut | Human scFv |
HPAB-0212CQ-S(P) | Human Anti-IGF1R Recombinant Antibody (clone 11A4); scFv Fragment | ELISA, FC, Block | Human scFv |
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TAB-052ZJ-S(P) | Anti-Human IGF-1R Recombinant Antibody scFv Fragment (TAB-052ZJ-S(P)) | ELISA, FC, IF, IP | Human antibody |
TAB-053ZJ-S(P) | Anti-Human IGF-1R Recombinant Antibody scFv Fragment (IR3) | ELISA, FC, WB | Human antibody |
TAB-054ZJ-S(P) | Anti-Human IGF-1R Recombinant Antibody scFv Fragment (IR10) | ELISA, FC, WB | Human antibody |
TAB-055ZJ-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-055ZJ-S(P)) | ELISA | Human scFv |
TAB-056ZJ-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-056ZJ-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
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TAB-009ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-009ZJ-F(E)) | ELISA, FC | Mouse Fab |
TAB-010ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11) | ELISA, Neut, FC, IHC | |
TAB-011ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-011ZJ-F(E)) | ELISA, FC, WB, Inhib | Mouse Fab |
TAB-012ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-012ZJ-F(E)) | ELISA, FC, WB, Inhib | Mouse Fab |
TAB-014ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-014ZJ-F(E)) | ELISA, FC, Inhib, IP | Mouse Fab |
CAT | Product Name | Application | Type |
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TAB-035ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-035ZJ-F(E)) | ELISA, FC | Humanized Fab |
TAB-036ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (H0L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
TAB-037ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (H1L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
TAB-038ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-038ZJ-F(E)) | ELISA, FC, Inhib, IP | Humanized Fab |
TAB-051ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-051ZJ-F(E)) | ELISA, IHC, IF, WB | Humanized Fab |
CAT | Product Name | Application | Type |
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TAB-084ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-084ZJ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
TAB-085ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11c) | ELISA, Neut, FC, IHC | Chimeric antibody (mouse/human) |
TAB-086ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-086ZJ-F(E)) | ELISA, FC, Inhib, IP | Chimeric (mouse/human) Fab |
TAB-087ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (ch7C2) | ELISA | Chimeric antibody (mouse/human) |
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CAT | Product Name | Application | Type |
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NEUT-1075CQ | Mouse Anti-IGF1R Recombinant Antibody (clone alphaIR3) | FC, IP, Neut, ICC, IF | Mouse IgG1 |
NEUT-1076CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 33255.111) | ELISA, Neut, WB | Mouse IgG1 |
NEUT-1081CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL453) | WB, ELISA, Neut | Mouse IgG1 |
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NEUT-1077CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 1H7) | FC, Block, IHC, IP, WB | Mouse IgG1, κ |
NEUT-1078CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-60) | Inhib, ICC, IF, IP, WB | Mouse IgG2a, κ |
NEUT-1079CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 17-69) | Inhib, IP | Mouse IgG1 |
NEUT-1080CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-57) | Inhib, IP | Mouse IgG1, κ |
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MOR-1755 | Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB) | IP, ELISA | Rabbit IgG |
MOR-4684 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH198DS) | WB, ELISA | Rabbit IgG |
MOR-4685 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH199DS) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
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NS-041CN | Mouse Anti-IGF1R Recombinant Antibody (NS-041CN) | ELISA, WB, FC | Mouse IgG |
NS-041CN-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (NS-041CN-F(E)) | ELISA, WB, FC | Mouse Fab |
NS-041CN-S(P) | Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P)) | ELISA, WB, FC | Mouse scFv |
CAT | Product Name | Application | Type |
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HPAB-0210CQ-F(E) | Human Anti-IGF1R Recombinant Antibody (clone 15H12); Fab Fragment | ELISA, FC, Neut | Human Fab |
HPAB-1441LY-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-1441LY-F(E)) | ELISA, IHC | Humanized Fab |
HPAB-1442LY-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-1442LY-F(E)) | ELISA, IHC | Humanized Fab |
HPAB-0069-YJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0069-YJ-F(E)) | ELISA, Block, FC, FuncS | Human Fab |
HPAB-1732-FY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-1732-FY-S(P)) | WB, ELISA | Human scFv |
CAT | Product Name | Application | Type |
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VS-0424-XY145 | AbPlus™ Anti-IGF1R Magnetic Beads (9E11) | IP, Protein Purification |
CAT | Product Name | Application | Type |
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VS-0125-FY20 | Human Anti-IGF1R (clone 1H3) scFv-Fc Chimera | ELISA, FC, Neut, Inhib | Human IgG1, scFv-Fc |
VS-0325-FY85 | Human Anti-IGF1R (clone 7C10) scFv-Fc Chimera | ELISA, FC, Inhib | Human IgG1, scFv-Fc |
CAT | Product Name | Application | Type |
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VS-0325-XY1101 | Anti-IGF1R Immunohistochemistry Kit | IHC | |
VS-0525-XY3431 | Anti-Mouse IGF1R Immunohistochemistry Kit | IHC | |
VS-0525-XY3430 | Anti-Human IGF1R Immunohistochemistry Kit | IHC | |
VS-0525-XY3432 | Anti-Rat IGF1R Immunohistochemistry Kit | IHC |
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