IGF1-PE immunotoxin (CAT#: AGTO-L024E)

This immunotoxin was achieved by conjugating/fusing the IGF1 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cancer cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of breast, prostate, and lung cancers.


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Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Human
  • Species Reactivity
  • Human
  • Molecule Class
  • IGF1-PE
  • Toxin Description
  • Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • Breast, prostate, and lung cancers

Target

  • Alternative Names
  • IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE35

Related Resources

  • Related Signaling Pathways
  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Immunotoxin

CAT Product Name Application Type
AGTO-L024D IGF1-DT immunotoxin Cytotoxicity assay, Functional assay

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-371CL Afuco™ Anti-Human IGF1R Antibody, ADCC Enhanced (AFC-371CL) ELISA ADCC enhanced antibody
AFC-TAB-199 Afuco™ Anti-IGF1R Recombinant Antibody (AFC-TAB-199), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF Human IgG1, κ
AFC-TAB-209 Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Robatumumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody
AFC-TAB-736 Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Dalotuzumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody
AFC-TAB-078 Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Cixutumumab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

Human Antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-084ZJ-F(E) Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-084ZJ-F(E)) ELISA, FC Chimeric (mouse/human) Fab
TAB-085ZJ-F(E) Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11c) ELISA, Neut, FC, IHC Chimeric antibody (mouse/human)
TAB-086ZJ-F(E) Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-086ZJ-F(E)) ELISA, FC, Inhib, IP Chimeric (mouse/human) Fab
TAB-087ZJ-F(E) Anti-Human IGF-1R Recombinant Antibody Fab Fragment (ch7C2) ELISA Chimeric antibody (mouse/human)
TAB-093ZJ-F(E) Anti-Human IGF-1R Recombinant Antibody Fab Fragment (ch9E11) ELISA Chimeric antibody (mouse/human)

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0103MZ Chicken Anti-CD221 Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1077CQ Mouse Anti-IGF1R Recombinant Antibody (clone 1H7) FC, Block, IHC, IP, WB Mouse IgG1, κ
NEUT-1078CQ Mouse Anti-IGF1R Recombinant Antibody (clone 24-60) Inhib, ICC, IF, IP, WB Mouse IgG2a, κ
NEUT-1079CQ Mouse Anti-IGF1R Recombinant Antibody (clone 17-69) Inhib, IP Mouse IgG1
NEUT-1080CQ Mouse Anti-IGF1R Recombinant Antibody (clone 24-57) Inhib, IP Mouse IgG1, κ

Recombinant Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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