IL2-RTA immunotoxin

Name: IL2-RTA immunotoxin
SKU: AGTO-L078R
Rating: 5 (1 reviews)

CAT#: AGTO-L078R

This immunotoxin was achieved by conjugating/fusing the IL-2 to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to T cell leukaemia cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of T cell leukaemia.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA

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Specifications

Host Species
Human

Species Reactivity
Human

Molecule Class
IL2-RTA

Toxin Description
Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.

Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.

Related Disease
T cell leukaemia

Target

Alternative Names
CD25; IDDM10; IL 2 RA; IL 2 receptor subunit alpha; IL 2R alpha chain; IL 2R subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2 RA; IL2 Receptor alpha; IL2 receptor subunit alpha; IL2-RA; IL2R alpha chain; IL2R; IL2R subunit alpha; IL2RA; IL2RA_HUMAN; Interleukin 2 receptor alpha chain; interleukin 2 receptor subunit alpha; Interleukin 2 receptor, alpha; Interleukin-2 receptor subunit alpha; Ly 43; Ly43; OTTHUMP00000019030; OTTHUMP00000019031; OTTHUMP00000019032; p55; p55 chain; T Cell Growth Factor Receptor; TAC antigen; TCGFR; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

Gene ID
3559

UniProt ID
P01589

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AGTO-L078R.pdf

MSDS

MSDS - AGTO-L078R.pdf

COA

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