Idursulfase (CAT#: TP-019CL)
Idursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. Idursulfase is produced by recombinant DNA technology in a human cell line. Idursulfase is an enzyme that hydrolyzes the 2-sulfate esters of terminal iduronate sulfate residues from the glycosaminoglycans dermatan sulfate and heparan sulfate in the lysosomes of various cell types. Idursulfase is a 525-amino acid glycoprotein with a molecular weight of approximately 76 kilodaltons. The enzyme contains eight asparagine-linked glycosylation sites occupied by complex oligosaccharide structures. The enzyme activity of idursulfase is dependent on the post-translational modification of a specific cysteine to formylglycine.
Specifications
- Classify
- Protein therapeutics replacing a protein that is deficient or abnormal: Metabolic enzyme deficiencies
- Therapeutic
- Idursulphase (iduronate-2-sulphatase)
- Trade Name
- Elaprase
- Function
- Cleaves the terminal 2-O-sulphate moieties from the GAGs dermatan sulphate and heparan sulphate, thereby allowing their digestion and preventing GAG accumulation
- Examples of clinical use
- Mucopolysaccharidosis ii (Hunter syndrome)
References
- Synonyms
- Alpha-L-iduronate sulfate sulfatase, Iduronate 2-sulfatase
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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