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Kunitz domains anti-KLK1 (SKD-L106)

The Kunitz domain that bound plasma kallikrein was isolated from the library using Phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=11 pM) for plasma kallikrein as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      
Datasheet
Specifications
Scaffold Name
Kunitz domains
Origin
BPTI/APPI
Core Structure
α-helices, β-sheets
Variable Regions
1–2 Loops
Target
Pasma kallikrein
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
11 pM
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
BPTI/APPI; Kunitz domains; hK1; KLKR; Klk6
Entrez Gene ID
3816
UniProt ID
P06870

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Recombinant Human Anti-KLK1 Antibody Fab Fragment (M0137-E01)    ( HPAB-0139-CN-F(E) )
Recombinant Human Anti-KLK1 Antibody scFv Fragment (M0137-E01)    ( HPAB-0139-CN-S(P) )
Recombinant Anti-Human KLK1 Antibody Fab Fragment    ( MOB-1984z-F(E) )
Recombinant Human Anti-KLK1 Antibody Fab Fragment (M0093-F09)    ( HPAB-0138-CN-F(E) )
Recombinant Human Anti-KLK1 Antibody scFv Fragment (M0093-F09)    ( HPAB-0138-CN-S(P) )
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