Kunitz domains scaffold protein anti-Human Pasma kallikrein (CAT#: SKD-L106)
The Kunitz domain that bound plasma kallikrein was isolated from the library using Phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=11 pM) for plasma kallikrein as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human salivary gland
(Immunohistochemical staining of human salivary gland shows strong positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_B_3_1_selected.jpg
(Immunohistochemical staining of human salivary gland shows strong positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_B_3_1_selected.jpg
Figure 1 Salivary gland
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_B_3_1.jpg
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_B_3_1.jpg
Figure 2 Colon
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_A_9_3.jpg
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_A_9_3.jpg
Figure 1 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_A_8_5.jpg
Figure 2 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_A_6_6.jpg
Figure 3 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_A_8_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/59690/133731_A_8_8.jpg
Figure 4 RNA cell line category: Cell line enriched (RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167748-KLK1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167748-KLK1
Specifications
- Scaffold Name
- Kunitz domains
- Origin
- BPTI/APPI
- Core Structure
- α-helices, β-sheets
- Variable Regions
- 1–2 Loops
- Target
- Pasma kallikrein
- Species Reactivity
- Human
- Expression Host
- E. coli
- Affinity Constant
- 11 pM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4291 | Hi-Affi™ Recombinant Rabbit Anti-KLK1 Monoclonal Antibody (SI377DS) | ELISA | IgG |
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