Kunitz domains anti-trypsin (SKD-L110)
The Kunitz domain that bound trypsin was isolated from the library using Phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=7 nM) for trypsin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specifications
- Scaffold Name
- Kunitz domains
- Origin
- hTFPI-2/KD1
- Core Structure
- α-helices, β-sheets
- Variable Regions
- 1–2 Loops
- Target
- Trypsin
- Species Reactivity
- Human
- Expression Host
- E. coli
- Affinity Constant
- 7 nM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- hTFPI-2/KD1; Kunitz domains; trypsin
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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