Anti-Canine IL31 Recombinant Antibody (Lokivetmab) (CAT#: TAB-419CQ)
Recombinant monoclonal antibody to IL31. Lokivetmab is a caninized monoclonal antibody that can be potentially used in the treatment of Canine atopic dermatitis (AD).
Specific Inquiry
Figure 1 Percentage reduction from baseline Owner Pruritus Visual Analog Scale (VAS) score (±SE) following subcutaneous administration of placebo or lokivetmab once on Day 0. See for number of dogs on study per treatment group at each day of study.
* significantly different from placebo (P < 0.05; range, <0.0001–0.0426); + significantly different from 0.125 mg/kg lokivetmab (P < 0.05; range, 0.0002–0.0467); ! significantly different from 0.5 mg/kg lokivetmab (P<0.05; range, 0.0167–0.0333).
Michels, G. M., Ramsey, D. S., Walsh, K. F., Martinon, O. M., Mahabir, S. P., & Hoevers, J. D., et al. . A blinded, randomized, placebo‐controlled, dose determination trial of lokivetmab (zts‐00103289), a caninized, anti‐canine il‐31 monoclonal antibody in client owned dogs with atopic dermatitis. Veterinary Dermatology, 27(6), 1.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Canine
- Derivation
- Caninized
- Type
- IgG2, κ
- Specificity
- Canine IL31
- Species Reactivity
- Canine
- Applications
- ELISA, IHC, FC, IP, IF, FuncS
- Conjugate
- Unconjugated
- CAS
- 1533403-95-0
- Generic Name
- Lokivetmab
- UNII
- 3D6091GOHH
- Related Disease
- Canine atopic dermatitis (AD)
Product Property
- Purity
- > 95% as determined by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The IL31 antibody has been reported in applications of Inhib.
Target
Related Resources
Please refer to Lokivetmab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Lokivetmab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Lokivetmab"
Afuco™ Anti-IL31 ADCC Recombinant Antibody (Lokivetmab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL31. Lokivetmab is a caninized monoclonal antibody that can be potentially used in the treatment of Canine atopic dermatitis (AD).
See other products for "IL31"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1474-sdAb | Recombinant Anti-Human IL31 VHH Single Domain Antibody | ICC, ChiP, FC, FA | Llama VHH |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1385CQ | Mouse Anti-IL31 Recombinant Antibody (VMC200) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4266 | Rabbit Anti-Il31 Recombinant Antibody (clone SI348DS) | ELISA | Rabbit IgG |
| MOR-4617 | Rabbit Anti-IL31 Recombinant Antibody (clone TH130DS) | WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0131-LSX | Mouse Anti-IL31 Recombinant Antibody (HPAB-0131-LSX) | ELISA, WB | Mouse IgG |
| HPAB-0132-LSX | Mouse Anti-IL31 Recombinant Antibody (HPAB-0132-LSX) | ELISA, WB, Inhib | Mouse IgG |
| HPAB-0133-LSX | Mouse Anti-IL31 Recombinant Antibody (HPAB-0133-LSX) | ELISA, WB | Mouse IgG |
| HPAB-0134-LSX | Canine Anti-IL31 Recombinant Antibody (HPAB-0134-LSX) | ELISA, WB | Canine IgG |
| HPAB-0135-LSX | Canine Anti-IL31 Recombinant Antibody (HPAB-0135-LSX) | ELISA, WB | Canine IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0131-LSX-S(P) | Mouse Anti-IL31 Recombinant Antibody; scFv Fragment (HPAB-0131-LSX-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0132-LSX-S(P) | Mouse Anti-IL31 Recombinant Antibody; scFv Fragment (HPAB-0132-LSX-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0133-LSX-S(P) | Mouse Anti-IL31 Recombinant Antibody; scFv Fragment (HPAB-0133-LSX-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0134-LSX-S(P) | Canine Anti-IL31 Recombinant Antibody; scFv Fragment (HPAB-0134-LSX-S(P)) | ELISA, WB | Canine scFv |
| HPAB-0135-LSX-S(P) | Canine Anti-IL31 Recombinant Antibody; scFv Fragment (HPAB-0135-LSX-S(P)) | ELISA, WB | Canine scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0131-LSX-F(E) | Mouse Anti-IL31 Recombinant Antibody; Fab Fragment (HPAB-0131-LSX-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0132-LSX-F(E) | Mouse Anti-IL31 Recombinant Antibody; Fab Fragment (HPAB-0132-LSX-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0133-LSX-F(E) | Mouse Anti-IL31 Recombinant Antibody; Fab Fragment (HPAB-0133-LSX-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0134-LSX-F(E) | Canine Anti-IL31 Recombinant Antibody; Fab Fragment (HPAB-0134-LSX-F(E)) | ELISA, WB | Canine Fab |
| HPAB-0135-LSX-F(E) | Canine Anti-IL31 Recombinant Antibody; Fab Fragment (HPAB-0135-LSX-F(E)) | ELISA, WB | Canine Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-419CQ | Afuco™ Anti-IL31 ADCC Recombinant Antibody (Lokivetmab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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