Anti-CD103 (clone M290)-MCC-DM1 ADC (CAT#: ADC-091LZY)

• Antibody Overview
• Anti-Mouse CD103 mAb,M290

• Clone
• M290

• Linker
• MCC (4-(Nmaleimidomethyl)cyclohexane-1 carboxylate)

• Linker Class/Description
• Class: Noncleavable linker
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation

• Drug
• DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

• Introduction
• Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

• Alternative Names
• ITGAE; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); CD103; HUMINAE; integrin alpha-E; HML-1 antigen; integrin alpha-IEL; mucosal lymphocyte 1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide;

• Gene ID
• 3682

• UniProt ID
• P38570

• AGTO-G046S
• Anti-Itgae immunotoxin M290 (IgG)-Sap

• ADC-089LZY
• Anti-CD103 (clone M290)-mc-vc-PABc-MMAE ADC

• ADC-090LZY
• Anti-CD103 (clone M290)-mc-MMAF ADC

• FN-104CQ
• Recombinant Rat Anti-ITGAE Antibody (M290)

• AGTO-G046S-mRNA
• Rat Anti-Itgae Antibody (clone M290), mRNA

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