Anti-CD103 (clone M290)-MCC-DM1 ADC
CAT#: ADC-091LZY
This ADC product is composed of an anti-CD103 antibody (clone M290) conjugated via MCC linker to DM1 (M290-MCC-DM1). It has demonstrated a response in islet allograft rejection treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows distinct cytoplasmic positivity in intra-epithelial lymphocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36313/ihc_selected.jpg
Normal Tissue
Figure 2 High expression in small intestine
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_4_2_selected.jpg
Normal Tissue
Figure 3 Low expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_B_9_5_val_selected.jpg
Normal Tissue
Figure 4 Colon
Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52147/168912_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000083457-ITGAE
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Specifications
- Antibody Overview
- Anti-Mouse CD103 mAb,M290
- Clone
- M290
- Linker
- MCC (4-(Nmaleimidomethyl)cyclohexane-1 carboxylate)
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
- Alternative Names
- ITGAE; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); CD103; HUMINAE; integrin alpha-E; HML-1 antigen; integrin alpha-IEL; mucosal lymphocyte 1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide;
- Gene ID
- 3682
- UniProt ID
- P38570
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