Anti-CD103 (clone M290)-mc-MMAF ADC (CAT#: ADC-090LZY)

• Antibody Overview
• Anti-Mouse CD103 mAb,M290

• Clone
• M290

• Linker
• mc(maleimidocaproyl)

• Linker Class/Description
• Class: Noncleavable linker
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation

• Drug
• MMAF(monomethyl auristatin F)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

• Alternative Names
• ITGAE; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); CD103; HUMINAE; integrin alpha-E; HML-1 antigen; integrin alpha-IEL; mucosal lymphocyte 1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide;

• Gene ID
• 3682

• UniProt ID
• P38570

• AGTO-G046S
• Anti-Itgae immunotoxin M290 (IgG)-Sap

• ADC-089LZY
• Anti-CD103 (clone M290)-mc-vc-PABc-MMAE ADC

• ADC-091LZY
• Anti-CD103 (clone M290)-MCC-DM1 ADC

• FN-104CQ
• Recombinant Rat Anti-ITGAE Antibody (M290)

• AGTO-G046S-mRNA
• Rat Anti-Itgae Antibody (clone M290), mRNA

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