Anti-CD103 (clone M290)-mc-MMAF ADC (CAT#: ADC-090LZY)

This ADC product is composed of an anti-CD103 antibody (clone M290) conjugated via mc linker to MMAF (M290-mc-MMAF). It has demonstrated a response in islet allograft rejection treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Anti-Mouse CD103 mAb,M290
  • Clone
  • M290
  • Linker
  • mc(maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • MMAF(monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • ITGAE; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); CD103; HUMINAE; integrin alpha-E; HML-1 antigen; integrin alpha-IEL; mucosal lymphocyte 1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide;

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Immunotoxin

CAT Product Name Application Type
AGTO-G046S Anti-Itgae immunotoxin M290 (IgG)-Sap Cytotoxicity assay, Function study

Chimeric Antibody

CAT Product Name Application Type
TAB-744LC Anti-human ITGAE Recombinant Antibody (5E4 (IgG1)) (TAB-744LC) ELISA, FC Chimeric antibody (mouse/human)
TAB-745LC Anti-human ITGAE Recombinant Antibody (3G6 (IgG1)) (TAB-745LC) FC Chimeric antibody (mouse/human)
TAB-744LC-S(P) Anti-human ITGAE scFv Fragment (5E4 (IgG1)) ELISA, FC Chimeric antibody (mouse/human)
TAB-744LC-F(E) Anti-human ITGAE Fab Fragment (5E4 (IgG1)) ELISA, FC Chimeric antibody (mouse/human)
TAB-745LC-F(E) Anti-human ITGAE Fab Fragment (3G6 (IgG1)) ELISA, FC Chimeric antibody (mouse/human)

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0296MZ Chicken Anti-ITGAE Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1558CQ Recombinant Rat Anti-Itgae Antibody (MAB0828) BL, FC, IHC-Fr, IP IgG2

Rabbit Monoclonal Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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