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Min-23 scaffold protein anti-Human DLL4 (CAT#: SMI-L141)

The Min-23 that bound DLL4 was isolated from the library using ribosome display techonology. After affinity maturation, Min-23 variants were identified having affinities (KD=43.56 nM) for DLL4 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.


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Normal Tissue
Figure 1 IHC staining of human small intestine
Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_2_selected.jpg
Figure 2 Colon
Figure 2 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_9_3.jpg
Figure 3 Liver
Figure 3 Liver
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_4.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_5.jpg
Figure 5 Testis
Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (BJ hTERT+, HUVEC TERT2, SCLC-21H)
Figure 6 RNA cell line category: Group enriched (BJ hTERT+, HUVEC TERT2, SCLC-21H)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128917-DLL4

Specifications

  • Scaffold Name
  • Min-23
  • Origin
  • Min-23
  • Core Structure
  • Triple-stranded β-sheet
  • Variable Regions
  • b-turn
  • Target
  • DLL4
  • Species Reactivity
  • Human
  • Expression Host
  • E. coli
  • Affinity Constant
  • 43.56 nM
  • Applications
  • ELISA; IHC; Microscopy; FC; WB; FuncS

Target

  • Alternative Names
  • Min-23; Min-23; AOS6; hdelta2

Downloads

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See other products for "DLL4"

Humanized Antibody

CAT Product Name Application Type
TAB-204 Anti-Human DLL4 Recombinant Antibody (Demcizumab) ELISA, FC, IP, FuncS, IF, Neut, WB IgG2 - kappa

Rat Antibody

CAT Product Name Application Type
TAB-217CL Human Anti-DLL4 Recombinant Antibody (TAB-217CL) WB, IHC, IF, FC, Inhib Human IgG

Mouse Antibody

CAT Product Name Application Type
TAB-216MZ Mouse Anti-DLL4 Recombinant Antibody (TAB-216MZ) FC, FuncS Mouse IgG
TAB-216MZ-S(P) Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-216MZ-S(P)) FC Mouse scFv
TAB-216MZ-F(E) Mouse Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-216MZ-F(E)) FC Mouse Fab
TAB-227MZ-F(E) Anti-Human DLL4 Recombinant Antibody Fab Fragment (1C1) ELISA, FC
TAB-232MZ-F(E) Rat Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-232MZ-F(E)) ELISA, FC Rat Fab

Chimeric Antibody

CAT Product Name Application Type
TAB-217MZ Human Anti-DLL4 Recombinant Antibody (TAB-217MZ) FC, FuncS Chimeric (mouse/human) IgG
TAB-217MZ-S(P) Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-217MZ-S(P)) FC Mouse scFv
TAB-217MZ-F(E) Human Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-217MZ-F(E)) FC Chimeric antibody (mouse/human)

Human Antibody

CAT Product Name Application Type
TAB-218MZ-F(E) Human Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-218MZ-F(E)) ELISA, FC Human Fab
TAB-219MZ-F(E) Human Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-219MZ-F(E)) ELISA, FC Human Fab
TAB-220MZ-F(E) Human Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-220MZ-F(E)) ELISA, FC Human Fab
TAB-221MZ-F(E) Human Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-221MZ-F(E)) ELISA, FC Human Fab
TAB-222MZ-F(E) Human Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-222MZ-F(E)) FC Human Fab

Recombinant Antibody

CAT Product Name Application Type
MOB-0202CT Recombinant Mouse anti-Human DLL4 Monoclonal antibody (4A11) ELISA, FC, WB
HPAB-0207-CN Human Anti-DLL4 Recombinant Antibody (HPAB-0207-CN) ELISA, WB, FC, IHC, IF, ICC Chimeric (mouse/human) IgG1, κ
HPAB-0156CQ Human Anti-DLL4 Recombinant Antibody (clone YW26.82) ELISA, FC, IHC, Block Human IgG1, κ
FN-220CQ Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-1) FC, FuncS, IF Hamster IgG
HPAB-0211-WJ Mouse Anti-DLL4 Recombinant Antibody (clone MMGZ01) ELISA Mouse IgG

Blocking Antibody

CAT Product Name Application Type
NEUT-707CQ Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-2) Block Hamster IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4140 Hi-Affi™ Rabbit Anti-DLL4 Recombinant Antibody (clone SI213DS) ELISA Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0203-CN-F(E) Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0203-CN-F(E)) ELISA, WB, FC, IP Human Fab
HPAB-0204-CN-F(E) Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0204-CN-F(E)) ELISA, WB, FC, IP Human Fab
HPAB-0205-CN-F(E) Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0205-CN-F(E)) ELISA, WB, FC, IP Human Fab
HPAB-0206-CN-F(E) Mouse Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0206-CN-F(E)) ELISA, WB, FC, IHC, IF, ICC Mouse Fab
HPAB-0208-CN-F(E) Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0208-CN-F(E)) ELISA, WB, FC, IHC, IF, ICC Humanized Fab

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0155-LSX-S(P) Mouse Anti-DLL4 Recombinant Antibody (clone 2H10); scFv Fragment ELISA, FC Mouse scFv
HPAB-0142-FY-S(P) Human Anti-DLL4 Recombinant Antibody (clone 12.3 1 C1); scFv Fragment ELISA Human scFv
HPAB-0716-FY-F(E) Mouse Anti-DLL4 Recombinant Antibody (clone AB015); scFv Fragment FC Mouse scFv
HPAB-1108-FY-F(E) Human Anti-DLL4 Recombinant Antibody (clone 61B); scFv Fragment ELISA Human scFv
HPAB-1109-FY-F(E) Human Anti-DLL4 Recombinant Antibody (clone 2-6); scFv Fragment ELISA Human scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-204 Afuco™ Anti-DLL4 ADCC Recombinant Antibody (Demcizumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

Single-domain Antibody

CAT Product Name Application Type
HPAB-1512-FY Recombinant Llama Anti-DLL4 Single Domain Antibody (56A09) Block, ELISA, FC Llama VHH
HPAB-1513-FY Recombinant Llama Anti-DLL4 Single Domain Antibody (56H08) Block, ELISA, FC Llama VHH
HPAB-1514-FY Recombinant Llama Anti-DLL4 Single Domain Antibody (104G01) Block, ELISA, FC Llama VHH

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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