Oprelvekin, the active ingredient in Neumega® is recombinant Interleukin eleven, which is produced in Escherichia coli (E. coli) by recombinant DNA technology. The protein has a molecular mass of approximately 19,000 daltons, and is non-glycosylated. The polypeptide is 177 amino acids in length (the natural IL-11 has 178). This alteration has not resulted in measurable differences in bioactivity either in vitro or in vivo.
The primary hematopoietic activity of Neumega® is stimulation of megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies Neumega® has shown potent thrombopoietic activity in compromised hematopoiesis, including moderately to severely myelosuppressed animals. In these studies, Neumega® improved platelet nadirs and accelerated platelet recoveries compared to controls.
In animal studies Oprelvekin also has non-hematopoetic activities. This includes the regulation of intestinal epithelium growth (enhanced healing of gastrointestinal lesions), the inhibition of adipogenesis, the induction of acute phase protein synthesis (e.g., fibrinogen), and inhibition of macrophageal released pro-inflammatory cytokines.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-551 | Recombinant Anti-human IL11 Antibody | WB, IP, FuncS | IgG |
MHH-551 | Recombinant Human Anti-human IL11 Antibody | FC, Neut, Funcs | IgG |
MOB-0777CT | Recombinant Mouse anti-Human IL11 Monoclonal antibody (LU73) | sELISA | |
ZG-0494J | Mouse Anti-IL11 Recombinant Antibody (ZG-0494J) | WB, ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-551-F(E) | Recombinant Anti-human IL11 Antibody Fab Fragment | WB, RIA, FuncS | Fab |
MHH-551-F(E) | Recombinant Human Anti-human IL11 Antibody Fab Fragment | WB, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-551-S(P) | Recombinant Anti-human IL11 Antibody scFv Fragment | WB, Neut, FuncS | scFv |
MHH-551-S(P) | Recombinant Human Anti-human IL11 Antibody scFv Fragment | WB, FC, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1142CQ | Mouse Anti-IL11 Recombinant Antibody (clone MM0361-9T27) | WB, Neut | Mouse IgG2 |
NEUT-1143CQ | Mouse Anti-IL11 Recombinant Antibody (clone P107) | Neut, ELISA | Mouse IgG1, κ |
NEUT-1144CQ | Mouse Anti-IL11 Recombinant Antibody (clone 27B1047.1) | ELISA, Neut, WB | Mouse IgG |
NEUT-1145CQ | Mouse Anti-IL11 Recombinant Antibody (clone CBL088) | Neut, WB | Mouse IgG2 |
NEUT-1146CQ | Mouse Anti-IL11 Recombinant Antibody (clone CBL265) | ELISA, Neut | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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