PDZ domain scaffold protein anti-Human ErbB4 (CAT#: SPD-L160)
The PDZ domain that bound ErbB4 was isolated from the library using Yeast Two-hybrid techonology. PDZ domains are modular protein-interaction domains that are specialized for binding to short peptide motifs at the extreme carboxy (C) termini of other proteins, athough they can also have other modes of interaction. After affinity maturation, PDZ domain variants were identified having affinities for ErbB4 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/ihc_selected.jpg
(Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/ihc_selected.jpg
Figure 2 Cerebral cortex
(Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_B_9_5.jpg
(Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_B_9_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_A_7_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_A_7_3.jpg
Figure 4 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_A_7_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_A_7_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_A_9_5.jpg
(Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_A_9_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_A_4_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_A_4_6.jpg
Figure 7 Placenta
(Decidual cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_A_1_7.jpg
(Decidual cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13537/29984_A_1_7.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196411-EPHB4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196411-EPHB4
Specifications
- Scaffold Name
- PDZ domain
- Origin
- PSD-95 protein
- Core Structure
- β-sheet
- Target
- ErbB4
- Species Reactivity
- Human
- Expression Host
- E. coli
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Downloads
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-001WM | Anti-Human EPHB4 Recombinant Antibody (MOR03640) | ELISA, FC | Human Antibody |
| TAB-002WM | Anti-Human EPHB4 Recombinant Antibody (30.35) | ELISA | Human Antibody |
| TAB-001WM-S(P) | Anti-Human EPHB4 Recombinant Antibody scFv Fragment (MOR03640) | ELISA, FC | Human Antibody |
| TAB-001WM-F(E) | Anti-Human EPHB4 Recombinant Antibody Fab Fragment (MOR03640) | ELISA, FC | Human Antibody |
| TAB-002WM-F(E) | Anti-Human EPHB4 Recombinant Antibody Fab Fragment (30.35) | ELISA | Human Antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-003WM | Mouse Anti-EPHB4 Recombinant Antibody (TAB-003WM) | IHC, WB, FC | Mouse IgG2b |
| TAB-003WM-S(P) | Mouse Anti-EPHB4 Recombinant Antibody; scFv Fragment (TAB-003WM-S(P)) | IHC, WB | Mouse scFv |
| TAB-003WM-F(E) | Mouse Anti-EPHB4 Recombinant Antibody; Fab Fragment (TAB-003WM-F(E)) | IHC, WB | Mouse Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1169 | Hi-Affi™ Rabbit Anti-EPHB4 Recombinant Antibody (clone DS1169AB), FITC | FC | Rabbit IgG |
| MOR-4157 | Hi-Affi™ Rabbit Anti-EphB4 Recombinant Antibody (clone SI232DS) | FC | Rabbit IgG |
| MOR-4158 | Hi-Affi™ Rabbit Anti-EphB4 Recombinant Antibody (clone SI233DS) | ELISA, FC | Rabbit IgG |
| MOR-4159 | Hi-Affi™ Rabbit Anti-EphB4 Recombinant Antibody (clone SI234DS) | ELISA | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0184-CN | Human Anti-EPHB4 Recombinant Antibody (clone 22E6) | ELISA, WB, IP | Humanized IgG1, κ |
| HPAB-0185-CN | Human Anti-EPHB4 Recombinant Antibody (clone 30C2) | ELISA, WB, IP | Humanized IgG1, κ |
| HPAB-0186-CN | Human Anti-EPHB4 Recombinant Antibody (clone 1E10) | ELISA, WB, IP | Humanized IgG1, κ |
| HPAB-0187-CN | Human Anti-EPHB4 Recombinant Antibody (clone 4F2) | ELISA, WB, IP | Humanized IgG1, κ |
| VS3-XY636 | Mouse Anti-EPHB4 Recombinant Antibody (clone 5B5) | ELISA, WB, IHC, ICC | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0184-CN-S(P) | Human Anti-EPHB4 Recombinant Antibody (clone 22E6); scFv Fragment | ELISA, WB, IP | Humanized scFv |
| HPAB-0185-CN-S(P) | Human Anti-EPHB4 Recombinant Antibody (clone 30C2); scFv Fragment | ELISA, WB, IP | Humanized scFv |
| HPAB-0186-CN-S(P) | Human Anti-EPHB4 Recombinant Antibody (clone 1E10); scFv Fragment | ELISA, WB, IP | Humanized scFv |
| HPAB-0187-CN-S(P) | Human Anti-EPHB4 Recombinant Antibody (clone 4F2); scFv Fragment | ELISA, WB, IP | Humanized scFv |
| HPAB-1128-FY-F(E) | Mouse Anti-EPHB4 Recombinant Antibody (clone MAB265); scFv Fragment | ELISA | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0184-CN-F(E) | Human Anti-EPHB4 Recombinant Antibody (clone 22E6); Fab Fragment | ELISA, WB, IP | Humanized Fab |
| HPAB-0185-CN-F(E) | Human Anti-EPHB4 Recombinant Antibody (clone 30C2); Fab Fragment | ELISA, WB, IP | Humanized Fab |
| HPAB-0186-CN-F(E) | Human Anti-EPHB4 Recombinant Antibody (clone 1E10); Fab Fragment | ELISA, WB, IP | Humanized Fab |
| HPAB-0187-CN-F(E) | Human Anti-EPHB4 Recombinant Antibody (clone 4F2); Fab Fragment | ELISA, WB, IP | Humanized Fab |
| HPAB-1128-FY-S(P) | Mouse Anti-EPHB4 Recombinant Antibody (clone MAB265); Fab Fragment | ELISA | Mouse Fab |
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