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PE-A*02:01/Human ATIC (NLYPFVKTV) MHC Tetramer (CAT#: MHC-LC1936)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human ATIC of peptide NLYPFVKTV covering 102-110 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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  • Gene Expression
  • Datasheet
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  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13462/669_C5_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13462/28451_B_8_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13462/28451_A_7_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13462/28451_A_8_5.jpg
Figure 5 Testis
Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13462/28451_A_6_6.jpg
Figure 6 Lymph node
Figure 6 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13462/28451_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138363-ATIC

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • ATIC
  • Antigen Species
  • Human
  • Peptide
  • NLYPFVKTV
  • Range
  • 102-110
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]
  • Alternative Names
  • ATIC; Bifunctional purine biosynthesis protein PURH; PURH; AICAR; AICARFT; IMPCHASE; HEL-S-70p

Downloads

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See other products for "ATIC"

Recombinant Antibody

CAT Product Name Application Type
ZG-0316F Mouse Anti-ATIC Recombinant Antibody (ZG-0316F) WB Mouse IgG
ZG-0502J Mouse Anti-ATIC Recombinant Antibody (ZG-0502J) WB Mouse IgG
ZG-0825F Mouse Anti-ATIC Antibody (clone F38 P7 H9) WB, IHC Mouse IgG1
VS3-QX81 Mouse Anti-ATIC Recombinant Antibody (clone 3H12-C9-H9) WB Mouse IgG1
VS4-WK42 Mouse Anti-ATIC Recombinant Antibody (VS4-WK42) ELISA, WB Mouse IgG1

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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