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    PE-A*02:01/Human LMNA (RLAVYIDRV) MHC Tetramer (CAT#: MHC-LC1922)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human LMNA of peptide RLAVYIDRV covering 41-49 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

    Specific Inquiry
    • Size:
    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line PC-3
    Figure 1 IF staining of human cell line PC-3
    (Immunofluorescent staining of human cell line PC-3 shows localization to nuclear speckles.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6523/1905_E12_1_selected.jpg
    Figure 2 IHC staining of human epididymis
    Figure 2 IHC staining of human epididymis
    (Immunohistochemical staining of human epididymis shows strong nuclear membrane positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/6660/ihc_selected.jpg
    Figure 3 IHC staining of human rectum
    Figure 3 IHC staining of human rectum
    (Immunohistochemical staining of human rectum shows strong nuclear membrane positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/ihc_selected.jpg
    Normal Tissue
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Glial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Neuronal cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_B_8_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endocrine cells
    Staining: High
    Intensity: Strong
    Endothelial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Enterocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Enterocytes - Microvilli
    Staining: High
    Intensity: Strong
    Fibroblasts
    Staining: High
    Intensity: Strong
    Goblet cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Mucosal lymphoid cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_9_3.jpg
    Figure 6 Liver
    Figure 6 Liver
    (Cholangiocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Hepatocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_7_4.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in glomeruli
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Cells in tubules
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_8_5.jpg
    Figure 8 Testis
    Figure 8 Testis
    (Leydig cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Peritubular cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Sertoli cells
    Staining: High
    Intensity: Strong
    Quantity:>75%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_6_6.jpg
    Figure 9 Skin
    Figure 9 Skin
    (Cells in basal layer
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Cells in granular layer
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Cells in spinous layer
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Endothelial cells
    Staining: High
    Intensity: Strong
    Fibrohistiocytic cells
    Staining: High
    Intensity: Strong
    Langerhans cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_B_9_1.jpg
    Figure 10 Lymph node
    Figure 10 Lymph node
    (Germinal center cells
    Staining: Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/4022/12055_A_7_8.jpg
    RNA Expression
    Figure 11 RNA cell line category: Low cell line specificity
    Figure 11 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160789-LMNA

    Specifications

    • Allele
    • A*02:01
    • Class
    • Class I
    • MHC Species
    • Human
    • Antigen
    • LMNA
    • Antigen Species
    • Human
    • Peptide
    • RLAVYIDRV
    • Range
    • 41-49
    • Conjugate
    • PE
    • Application
    • FCM

    Target

    • Antigen Introduction
    • The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
    • Alternative Names
    • LMNA; Lamin-A/C; FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; MADA; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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