PE-A*02:01/Human PSMB3 (GLATDVQTV) MHC Tetramer
CAT#: MHC-LC1926
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human PSMB3 of peptide GLATDVQTV covering 55-63 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- PSMB3
- Antigen Species
- Human
- Peptide
- GLATDVQTV
- Range
- 55-63
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]
- Alternative Names
- PSMB3; Proteasome subunit beta type-3; HC10-II
- Gene ID
- 5691
- UniProt ID
- P49720
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