PE-A*02:01/Human PSMB3 (GLATDVQTV) MHC Tetramer (CAT#: MHC-LC1926)

• Allele
• A*02:01

• Class
• Class I

• MHC Species
• Human

• Antigen
• PSMB3

• Antigen Species
• Human

• Peptide
• GLATDVQTV

• Range
• 55-63

• Conjugate
• PE

• Application
• FCM

• Antigen Introduction
• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]

• Alternative Names
• PSMB3; Proteasome subunit beta type-3; HC10-II

• Gene ID
• 5691

• UniProt ID
• P49720

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