PE-A*02:01/Human TYR (RIWSWLLGA) MHC Tetramer

CAT#: MHC-LC2927

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human TYR of peptide RIWSWLLGA covering 473-481 and A*02:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression
Figure 1 IF staining of human cell line SK-MEL-30 Figure 2 RNA cell line category: Cell line enriched (SK-MEL-30)

Specifications

  • Allele
  • A*02:01
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • TYR
  • Antigen Species
  • Human
  • Peptide
  • RIWSWLLGA
  • Range
  • 473-481
  • Conjugate
  • PE

Target

  • Antigen Introduction
  • The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
  • Alternative Names
  • TYR; Tyrosinase precursor; ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
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