PE-A*02:02/Human ARHGDIB (EMDKDDESL) MHC Tetramer (CAT#: MHC-LC3912)

• Allele
• A*02:02

• Class
• Class I

• MHC Species
• Human

• Antigen
• ARHGDIB

• Antigen Species
• Human

• Peptide
• EMDKDDESL

• Range
• 37-45

• Conjugate
• PE

• Application
• FCM

• Antigen Introduction
• Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

• Alternative Names
• ARHGDIB; Rho GDP-dissociation inhibitor 2; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2

• Gene ID
• 397

• UniProt ID
• P52566

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