PE-A*69:01/Human MCM4 (AHSTIMPRL) MHC Tetramer (CAT#: MHC-LC4354)

• Allele
• A*69:01

• Class
• Class I

• MHC Species
• Human

• Antigen
• MCM4

• Antigen Species
• Human

• Peptide
• AHSTIMPRL

• Range
• 694-702

• Conjugate
• PE

• Application
• FCM

• Antigen Introduction
• The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

• Alternative Names
• MCM4; DNA replication licensing factor MCM4; NKCD; CDC21; CDC54; NKGCD; hCdc21; P1-CDC21

• Gene ID
• 4173

• UniProt ID
• P33991

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