PE-A*69:01/Human PDHA1 (KSDPIMLLK) MHC Tetramer
CAT#: MHC-LC4345
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human PDHA1 of peptide KSDPIMLLK covering 13-21 and A*69:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47864/1645_G11_19_cr57b568f223f4d_selected.jpg
Normal Tissue
Figure 2 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47864/113115_B_5_6.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47487/113196_A_9_8.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47864/113115_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47864/113115_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47864/113115_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131828-PDHA1
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Specifications
- Allele
- A*69:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- PDHA1
- Antigen Species
- Human
- Peptide
- KSDPIMLLK
- Range
- 13-21
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- PDHA1; pyruvate dehydrogenase alpha 1; PDHA; PDHAD; PHE1A; PDHCE1A
- Gene ID
- 5160
- UniProt ID
- Q6LCA3
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2639 | Hi-Affi™ Recombinant Rabbit Anti-PDHA1 Monoclonal Antibody (DS2639AB) | WB, IHC-P, ICC, IF, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC4342 | PE-A*01:01/Human PDHA1 (KSDPIMLLK) MHC Tetramer | FCM | |
| MHC-LC4343 | PE-A*03:01/Human PDHA1 (KSDPIMLLK) MHC Tetramer | FCM | |
| MHC-LC4344 | PE-A*11:01/Human PDHA1 (KSDPIMLLK) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1195-CN | Recombinant Rabbit Anti-PDHA1 Monoclonal Antibody (JF996-0) | WB, IF, IHC, IP, FC | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY372 | Rabbit Anti-NHP PDHA1 Recombinant Antibody (VS-1024-XY372) | WB, IHC, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1601 | Anti-PDHA1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5281 | Anti-Mouse PDHA1 Immunohistochemistry Kit | IHC | |
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