PE-B*07:02/Human TOP2B (SPRYIFTML) MHC Tetramer (CAT#: MHC-LC4346)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human TOP2B of peptide SPRYIFTML covering 795-803 and B*07:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Allele
  • B*07:02
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • TOP2B
  • Antigen Species
  • Human
  • Range
  • 795-803
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • TOP2B; DNA topoisomerase II beta; TOPIIB; top2beta

Downloads

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See other products for "TOP2B"

Recombinant Antibody

CAT Product Name Application Type
MOB-2066z Mouse Anti-TOP2B Recombinant Antibody (clone 20B1) WB, ELISA, IF, IP Mouse IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3640 Rabbit Anti-TOP2B Recombinant Antibody (clone DS3640AB) WB, IHC, ICC Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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