PE-B*15:01/Human CCND2 (ATDFKFAMY) MHC Tetramer (CAT#: MHC-LC4365)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human CCND2 of peptide ATDFKFAMY covering 189-197 and B*15:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49138/if_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49138/if_selected.jpg
Figure 2 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54196/if_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54196/if_selected.jpg
Figure 3 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49138/110519_A_9_5.jpg
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49138/110519_A_9_5.jpg
Figure 4 Epididymis
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49138/110519_A_3_6.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49138/110519_A_3_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (AF22, HBEC3-KT, HDLM-2, Karpas-707, RH-30, RPMI-8226)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118971-CCND2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118971-CCND2
Specifications
- Allele
- B*15:01
- Class
- Class I
- Antigen
- CCND2
- Antigen Species
- Human
- Peptide
- ATDFKFAMY
- Range
- 189-197
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
- Alternative Names
- CCND2; G1/S-specific cyclin-D2; MPPH3; KIAK0002
- Gene ID
- 894
- UniProt ID
- P30279
Related Resources
Hedgehog Signaling Pathway
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2080z | Mouse Anti-CCND2 Recombinant Antibody (clone 33G12) | WB, ICC, IF | Mouse IgG2a |
| MOB-2383CT | Mouse Anti-CCND2 Recombinant Antibody (clone L7) | IF, FC, WB | Mouse IgG |
| ZG-0447F | Mouse Anti-CCND2 Recombinant Antibody (ZG-0447F) | WB | Mouse IgG |
| VS3-QX175 | Mouse Anti-CCND2 Recombinant Antibody (clone 6E11-G6-F5) | WB | Mouse IgG2b |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-263CQ | Mouse Anti-CCND2 Recombinant Antibody (clone CBL925) | FC, IF, IP, ICC, WB, Neut | Mouse IgG2a, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-264CQ | Mouse Anti-CCND2 Recombinant Antibody (clone DCS-3.1) | FC, Inhib, IF, IHC, IP, WB | Mouse IgG2a |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC2362 | PE-A*01:01/Human CCND2 (ATDFKFAMY) MHC Tetramer | FCM | |
| MHC-LC4363 | APC-A*01:01/Human CCND2 (ATDFKFAMY) MHC Tetramer | FCM | |
| MHC-LC4364 | PE-A*11:01/Human CCND2 (ATDFKFAMY) MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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