PE-B*27:05/Human PSMB1 (RRFFPYYVY) MHC Tetramer (CAT#: MHC-LC4418)

• Allele
• B*27:05

• Class
• Class I

• MHC Species
• Human

• Antigen
• PSMB1

• Antigen Species
• Human

• Peptide
• RRFFPYYVY

• Range
• 127-135

• Conjugate
• PE

• Application
• FCM

• Antigen Introduction
• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008]

• Alternative Names
• PSMB1; Proteasome subunit beta type-1 precursor; HC5; PSC5; PMSB1

• Gene ID
• 5689

• UniProt ID
• P20618

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