PE-B*40:02/Human INCENP (REFSKEPEL) MHC Tetramer (CAT#: MHC-LC839)

• Allele
• B*40:02

• Class
• Class I

• MHC Species
• Human

• Antigen
• INCENP

• Antigen Species
• Human

• Peptide
• REFSKEPEL

• Range
• 47-55

• Conjugate
• PE

• Application
• FCM

• Antigen Introduction
• In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis.

• Alternative Names
• INCENP; inner centromere protein

• Gene ID
• 3619

• UniProt ID
• Q9NQS7

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