APC-CD1d/α-GalCer MHC Tetramer
CAT#: MHC-LC660
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of α-GalCer and CD1d molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- CD1d
- Class
- Class I
- MHC Species
- Human
- Antigen
- α-GalCer
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- A galactocerebroside (or galactosylceramide) is a type of cerebroside consisting of a ceramide with a galactose residue at the 1-hydroxyl moiety.
- Alternative Names
- α-GalCer; α-galactosylceramide
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Essential for NKT Cell Analysis
The APC-CD1d/α-GalCer MHC Tetramer is vital for profiling NKT cell populations. Its precise detection capability significantly contributes to our understanding of NKT cell dynamics and functions in immune modulation, particularly in cancer studies.
Enhances Multicolor Flow Applications
Its compatibility with multiple fluorochromes in flow cytometry has enhanced our analysis of immune cell subsets, providing detailed insights into NKT cell phenotypes and their roles in immune responses.
Q&As
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What is the primary application of the APC-CD1d/α-GalCer MHC Tetramer?
A: The tetramer is used in flow cytometry to identify and analyze NKT cells that specifically recognize α-galactosylceramide (α-GalCer) presented by CD1d molecules. It is instrumental in studying immune responses, particularly in autoimmune and cancer research.
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What storage conditions are recommended for maintaining tetramer functionality?
A: Store the tetramer at 4°C, and avoid freeze-thaw cycles to preserve its performance. When needed for long-term use, it's advisable to aliquot to pQAent repeated freezing and thawing, ensuring consistent and reliable experimental results.
View the frequently asked questions answered by Creative Biolabs Support.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC659 | PE-CD1d/α-GalCer MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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