PE-DQB1*03:02/Human GAD2 (IARFKMFPEVKEK) MHC Tetramer (CAT#: MHC-LC3246)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human GAD2 of peptide IARFKMFPEVKEK covering 253-265 and DQB1*03:02 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.

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  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Allele
  • DQB1*03:02
  • Class
  • Class II
  • MHC Species
  • Human
  • Antigen
  • GAD2
  • Antigen Species
  • Human
  • Peptide
  • IARFKMFPEVKEK
  • Range
  • 253-265
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
  • Alternative Names
  • GAD2; Glutamate decarboxylase 2; GAD65

Related Resources

  • Related Diseases

Downloads

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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