PE-DRB1*01:01/Human PTPRN (MSSGSFINISV) MHC Tetramer (CAT#: MHC-LC3277)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human PTPRN of peptide MSSGSFINISV covering 499-509 and DRB1*01:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
We require custom production
Specifications
- Allele
- DRB1*01:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- PTPRN
- Antigen Species
- Human
- Peptide
- MSSGSFINISV
- Range
- 499-509
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
- Alternative Names
- PTPRN; Receptor-type tyrosine-protein phosphatase-like N precursor; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP
- Gene ID
- 5798
- UniProt ID
- Q16849
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