PE-DRB1*03:01/Human CD74 (LPKPPKPVSKMRMATPLLMGALPM) MHC Tetramer
CAT#: MHC-LC2327
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human CD74 of peptide LPKPPKPVSKMRMATPLLMGALPM and DRB1*03:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2506/if_selected.jpg
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Specifications
- Allele
- DRB1*03:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- CD74
- Antigen Species
- Human
- Peptide
- LPKPPKPVSKMRMATPLLMGALPM
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
- Alternative Names
- CD74; CD74 molecule; II; DHLAG; HLADG; Ia-GAMMA
- Gene ID
- 972
- UniProt ID
- P04233
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