PE-DRB1*04:01/Human HLA-DRB1 (VYPEVTVYPAKT) MHC Tetramer (CAT#: MHC-LC3346)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human HLA-DRB1 of peptide VYPEVTVYPAKT covering 124-135 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
We require custom production
Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_8_8.jpg
Figure 2 Tonsil
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_4_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_4_8.jpg
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, THP-1, U-266/70, U-698, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, THP-1, U-266/70, U-698, U-87 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- HLA-DRB1
- Antigen Species
- Human
- Peptide
- VYPEVTVYPAKT
- Range
- 124-135
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent beta subunit of HLA-DR. Several alleles of DRB1 (shared epitope alleles) are associated with an increased incidence of rheumatoid arthritis.
- Alternative Names
- HLA-DRB1; HLA class II histocompatibility antigen, DRB1-4 beta chain precursor
- UniProt ID
- P13760
Downloads
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Customer Reviews and Q&As
Customer Review
Q&As
Streamlined Flow Cytometry Use
This tetramer integrates seamlessly into our flow cytometry setup. The PE tag allows for high-resolution detection, helping us precisely quantify T cell populations specific to HLA-DRB1 alleles. Its reliability in consistency across batches has streamlined our assays significantly.
Great for Autoimmunity Studies
Studying rheumatoid arthritis at our lab has been revolutionized by incorporating this tetramer. Tracking specific T cells responding to HLA-DRB1 has never been clearer, providing better insight into the autoimmune pathways involved.
Reliable Tool for T Cell Analysis
Its precision in detecting specific T cell subtypes makes it invaluable. By facilitating high-sensitivity analysis, it supports both exploratory and confirmatory research, crucial for credible results.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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