PE-DRB1*04:01/Human HLA-DRB1 (VYPEVTVYPAKT) MHC Tetramer
CAT#: MHC-LC3346
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human HLA-DRB1 of peptide VYPEVTVYPAKT covering 124-135 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD4 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_8_8.jpg
Normal Tissue
Figure 2 Tonsil
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15400/34565_A_4_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, THP-1, U-266/70, U-698, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196126-HLA-DRB1
❮
❯
Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- HLA-DRB1
- Antigen Species
- Human
- Peptide
- VYPEVTVYPAKT
- Range
- 124-135
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent beta subunit of HLA-DR. Several alleles of DRB1 (shared epitope alleles) are associated with an increased incidence of rheumatoid arthritis.
- Alternative Names
- HLA-DRB1; HLA class II histocompatibility antigen, DRB1-4 beta chain precursor
- UniProt ID
- P13760
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Streamlined Flow Cytometry Use
This tetramer integrates seamlessly into our flow cytometry setup. The PE tag allows for high-resolution detection, helping us precisely quantify T cell populations specific to HLA-DRB1 alleles. Its reliability in consistency across batches has streamlined our assays significantly.
Great for Autoimmunity Studies
Studying rheumatoid arthritis at our lab has been revolutionized by incorporating this tetramer. Tracking specific T cells responding to HLA-DRB1 has never been clearer, providing better insight into the autoimmune pathways involved.
Reliable Tool for T Cell Analysis
Its precision in detecting specific T cell subtypes makes it invaluable. By facilitating high-sensitivity analysis, it supports both exploratory and confirmatory research, crucial for credible results.
Q&As
-
What is the primary application of the HLA-DRB1 MHC Tetramer?
A: The HLA-DRB1 MHC Tetramer is primarily used for flow cytometry analysis of CD4 T cells that are specific to the HLA-DRB1 antigen. It aids in identifying and analyzing individual antigen-specific T cell populations.
-
Can this product be used in cancer research?
A: Yes, it can be used to study the immune response in cancer, especially in understanding how CD4 T cells recognize tumor antigens presented by the HLA-DRB1 molecule.
-
How does the tetramer facilitate research into cellular immune responses?
A: By binding specific CD4 T cells, the tetramer enables detailed examination of cellular immune responses in various conditions like autoimmunity and cancer.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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