PE-DRB1*04:05/Human PTPRN (GVAGLLVALAV) MHC Tetramer (CAT#: MHC-LC3244)

• Allele
• DRB1*04:05

• Class
• Class II

• MHC Species
• Human

• Antigen
• PTPRN

• Antigen Species
• Human

• Peptide
• GVAGLLVALAV

• Range
• 586-596

• Conjugate
• PE

• Application
• FCM

• Antigen Introduction
• The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

• Alternative Names
• PTPRN; Receptor-type tyrosine-protein phosphatase-like N precursor; IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP

• Gene ID
• 5798

• UniProt ID
• Q16849

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