PE-H-2Kb/OVA (SIINFEKL) MHC Tetramer

Customer Review

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Michael White
20.Aug,23

Great for OVA MHC Tetramer

The PE-H-2Kb-OVA (257-264) MHC Tetramer has been excellent for our OVA MHC tetramer studies. Its specificity and sensitivity are outstanding, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.

Laura Scott
04.Nov,22

Effective and Dependable

We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for OVA MHC tetramer is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.

Brian Young
28.Jun,21

Consistent High-Quality Results

This antibody has proven to be consistent and dependable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for OVA MHC tetramer have been particularly beneficial.

Q&As

1. Is the PE-H-2Kb OVA 257-264 MHC Tetramer suitable for use in flow cytometry?

   A: Yes, the PE-H-2Kb OVA 257-264 MHC Tetramer (MHC-LC649) is suitable for use in flow cytometry. It allows for the detection and analysis of antigen-specific T cells.

2. What are the storage recommendations for the PE-H-2Kb OVA 257-264 MHC Tetramer?

   A: The recommended storage condition for the PE-H-2Kb OVA 257-264 MHC Tetramer (MHC-LC649) is at 2-8°C. It should be protected from light and should not be frozen.

3. Can the PE-H-2Kb OVA 257-264 MHC Tetramer be used in live-cell staining?

   A: Yes, the PE-H-2Kb OVA 257-264 MHC Tetramer (MHC-LC649) can be used in live-cell staining. It allows for the identification of live antigen-specific T cells.

4. How do you titrate the PE-H-2Kb OVA 257-264 MHC Tetramer for optimal use?

   A: It is recommended to titrate the PE-H-2Kb OVA 257-264 MHC Tetramer (MHC-LC649) starting at 1:50 and adjust based on the specific experimental conditions.

5. What is the application of PE-H-2Kb OVA 257-264 MHC Tetramer in immunological research?

   A: The PE-H-2Kb OVA 257-264 MHC Tetramer (MHC-LC649) is used to detect and quantify antigen-specific CD8+ T cells in immunological research, particularly in studies related to OVA-specific immune responses.

View the frequently asked questions answered by Creative Biolabs Support.

Citations

1. Banerjee, Anirban, et al. "Retargeting IL-2 signaling to NKG2D-expressing tumor-infiltrating leukocytes improves adoptive transfer immunotherapy." The Journal of Immunology 207.1 (2021): 333-343. https://doi.org/10.4049/jimmunol.2000926
   This study explores the use of a novel IL-2 mutant retargeted to NKG2D for the adoptive transfer of tumor-infiltrating leukocytes (TILs) in a murine model of malignant melanoma. Traditional IL-2 protocols for TIL expansion support the growth of both cytotoxic and regulatory T cells, leading to inconsistent therapeutic outcomes. The research demonstrates that the novel NKG2D-retargeted IL-2 (OMCPmutIL-2) preferentially expands cytotoxic T cells, including CD8+ T cells, NK cells, and γδ T cells, enhancing their tumor-homing abilities and providing superior tumor control compared to wild-type IL-2-expanded TILs.
   Creative Biolabs significantly contributed to this research by providing the H-2kb/OVA (SINFEKL) MHC Tetramer (Cat#: MHC-LC649). This product was essential for the detailed flow cytometric analysis and characterization of the TILs. The tetramer allowed for the precise identification and sorting of OVA-specific CD8+ T cells within the tumor microenvironment, facilitating the study of their expansion and function under the influence of the novel OMCPmutIL-2 cytokine. This contribution was crucial for demonstrating the superior tumor control achieved with the retargeted IL-2 therapy.

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