PE-H-2Kb/OVA (SIINFEKL) MHC Tetramer (CAT#: MHC-LC649)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of OVA-derived peptide of SIINFEKL sequence covering 257-264 and H-2Kb molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specific Inquiry
Specifications
- Allele
- H-2Kb
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- OVA
- Antigen Species
- Gallus gallus
- Peptide
- SIINFEKL
- Range
- 257-264
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up approximately 55% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor. The function of ovalbumin is unknown, although it is presumed to be a storage protein.
- Alternative Names
- OVA; Ovalbumin
- Gene ID
- 396058
- UniProt ID
- P01012
Related Resources
Banerjee, Anirban, et al. "Retargeting IL-2 signaling to NKG2D-expressing tumor-infiltrating leukocytes improves adoptive transfer immunotherapy." The Journal of Immunology 207.1 (2021): 333-343. https://doi.org/10.4049/jimmunol.2000926
This study explores the use of a novel IL-2 mutant retargeted to NKG2D for the adoptive transfer of tumor-infiltrating leukocytes (TILs) in a murine model of malignant melanoma. Traditional IL-2 protocols for TIL expansion support the growth of both cytotoxic and regulatory T cells, leading to inconsistent therapeutic outcomes. The research demonstrates that the novel NKG2D-retargeted IL-2 (OMCPmutIL-2) preferentially expands cytotoxic T cells, including CD8+ T cells, NK cells, and γδ T cells, enhancing their tumor-homing abilities and providing superior tumor control compared to wild-type IL-2-expanded TILs.
Creative Biolabs significantly contributed to this research by providing the H-2kb/OVA (SINFEKL) MHC Tetramer (Cat#: MHC-LC649). This product was essential for the detailed flow cytometric analysis and characterization of the TILs. The tetramer allowed for the precise identification and sorting of OVA-specific CD8+ T cells within the tumor microenvironment, facilitating the study of their expansion and function under the influence of the novel OMCPmutIL-2 cytokine. This contribution was crucial for demonstrating the superior tumor control achieved with the retargeted IL-2 therapy.
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC648 | BV421-H-2Kb/OVA (SIINFEKL) MHC Tetramer | FCM | |
| MHC-LC650 | APC-H-2Kb/OVA (SIINFEKL) MHC Tetramer | FCM | |
| MHC-LC651 | PE-H-2Kb/OVA (EIINFEKL) MHC Tetramer | FCM | |
| MHC-LC652 | APC-H-2Kb/OVA (EIINFEKL) MHC Tetramer | FCM | |
| MHC-LC653 | PE-H-2Kb/OVA (SIIGFEKL) MHC Tetramer | FCM |
Customer Reviews and Q&As
Customer Review
Q&As
Michael White
Great for OVA MHC Tetramer
Great for OVA MHC Tetramer
The PE-H-2Kb-OVA (257-264) MHC Tetramer has been excellent for our OVA MHC tetramer studies. Its specificity and sensitivity are outstanding, providing clear and reliable results. This antibody has significantly improved the accuracy of our experiments and saved us a lot of troubleshooting time.
20-Aug-23
Laura Scott
Effective and Dependable
Effective and Dependable
We incorporated this antibody into our immunoassays, and it has been a great asset. The specificity for OVA MHC tetramer is precise, allowing for accurate detection and analysis. The reliable performance has made it an invaluable tool in our lab.
04-Nov-22
Brian Young
Consistent High-Quality Results
Consistent High-Quality Results
This antibody has proven to be consistent and dependable in our assays. The high-quality, reproducible results have significantly improved our experiments, making it a crucial part of our research toolkit. The strong affinity and specificity for OVA MHC tetramer have been particularly beneficial.
28-Jun-21
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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