PE-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer

Name: PE-H-2Kb/Mouse Insr (GNYSFYAL) MHC Tetramer
SKU: MHC-LC1205
Rating: 5 (1 reviews)

CAT#: MHC-LC1205

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of Insr-derived peptide of GNYSFYAL covering 423-430 and H-2Kb molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/737_C10_2_selected.jpg

Subcellular Location Figure 2 IHC staining of human liver

Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/ihc_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36303/836_E10_2_blue_red_green.jpg

Normal Tissue Figure 4 Colon

landular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_9_3.jpg

Normal Tissue Figure 5 Liver

Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_4.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_7_5.jpg

Normal Tissue Figure 7 Testis

Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_6_6.jpg

Normal Tissue Figure 8 Skeletal muscle

Myocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_B_3_6.jpg

Normal Tissue Figure 9 Lymph node

Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36302/112008_A_8_8.jpg

RNA Expression Figure 10 RNA cell line category: Cell line enhanced (Karpas-707, U-266/70)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000171105-INSR

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Specifications

Allele
H-2Kb

Class
Class I

MHC Species
Mouse

Antigen
Insr

Antigen Species
Mouse

Peptide
GNYSFYAL

Range
423-430

Conjugate
PE

Application
FCM

Target

Antigen Introduction
This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis.

Alternative Names
Insr; insulin receptor; IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik

Gene ID
16337

UniProt ID
P15208

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Related Signaling Pathways

PPAR Signaling Pathway

Related Diseases

Type I Diabetes Mellitus

Downloadable Resources

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Datasheet

Datasheet - MHC-LC1205.pdf

MSDS

MSDS - MHC-LC1205.pdf

COA

Certificate of Analysis Lookup

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