Pegademase bovine (CAT#: TP-025CL)
Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life.
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/26_D7_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/26_D7_2_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/27_D7_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/27_D7_1_blue_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/28_D7_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/28_D7_1_blue_red_green.jpg
Figure 4 Duodenum
(Enterocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Enterocytes - Microvilli
Staining: Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/162544_A_7_2.jpg
(Enterocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Enterocytes - Microvilli
Staining: Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/162544_A_7_2.jpg
Figure 5 Testis
(Round or early spermatids
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/162544_A_5_6.jpg
(Round or early spermatids
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1399/162544_A_5_6.jpg
Figure 6 RNA cell line category: Group enriched (JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196839-ADA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196839-ADA
Figure 6 RNA cell line category: Group enriched (JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196839-ADA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000196839-ADA
Specifications
- Classify
- Protein therapeutics replacing a protein that is deficient or abnormal: Immunodeficiencies
- Therapeutic
- Adenosine deaminase (pegademase bovine, PeG-ADA)
- Trade Name
- Adagen
- Function
- Metabolizes adenosine, prevents accumulation of adenosine; purified from cows
- Examples of clinical use
- Severe combined immunodeficiency disease due to adenosine deaminase deficiency
References
- Synonyms
- Adenosine aminohydrolase, Adenosine deaminase
- UniProt
- P56658
- Genbank
- AF280603
Related Resources
Primary Immunodeficiency
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ADA"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1230z | Mouse Anti-ADA Recombinant Antibody (clone 20C10) | FC, IHC, WB | Mouse IgG2b |
| MRO-215-MZ | Mouse Anti-ADA Recombinant Antibody (clone ADA-1) | RIA, WB, IP | Mouse IgG |
| MOB-0430MZ | Recombinant Mouse Anti-Escherichia coli ada Antibody (clone BEB-2) | IP, RIA, WB | Mouse antibody |
| VS3-QX22 | Mouse Anti-ADA Recombinant Antibody (clone 608CT2.1.3) | WB | Mouse IgG1 |
| VS3-CJ221 | Mouse Anti-ADA Recombinant Antibody (VS3-CJ221) | WB | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0067 | Hi-Affi™ Rabbit Anti-ADA Recombinant Antibody (clone DS67AB) | ICC, IP, WB | Rabbit IgG |
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