Mouse Anti-SLC26A4 Recombinant Antibody (clone 20H3)
CAT#: MOB-3008z
This product is a mouse antibody that recognizes human SLC26A4. It can be used in the following applications: WB, IF, FuncS.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human caudate
Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42860/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42860/93878_B_8_5.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42860/93878_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42860/93878_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42860/93878_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, hTERT-RPE1, LHCN-M2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091137-SLC26A4
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Specifications
- Immunogen
- Human Solute Carrier Family 26 (Anion Exchanger), Member 4
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Mouse IgG2a, κ
- Specificity
- Human SLC26A4
- Species Reactivity
- Human
- Clone
- 20H3
- Applications
- WB, IF, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Western blot, Immunofluorescence, Functional Study.
Target
- Alternative Names
- SLC26A4; Solute Carrier Family 26 (Anion Exchanger), Member 4; Sodium-Independent Chloride/Iodide Transporter; Solute Carrier Family 26, Member 4; TDH2B; PDS; DFNB4
- UniProt ID
- O43511
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Reliable for Ion Transport Studies
The Mouse Anti-SLC26A4 Recombinant Antibody has proven reliable in our studies on cellular ion transport mechanisms. Its high specificity ensures accurate targeting of SLC26A4, facilitating detailed assessments of chloride and iodide transport processes, which are central to our research on hereditary hearing loss.
Consistent and Dependable Results
By using this antibody, we achieve consistent results in our Western blot and immunofluorescence assays. This consistency extends across different batches, underscoring its reliability for ongoing research projects focused on genetic disorders associated with SLC26A4 mutations.
Supports Detailed Immunofluorescence Studies
Providing strong and specific staining in immunofluorescence studies, the antibody helps visualize SLC26A4 distribution and density across tissues, offering insights into its physiological and pathological roles in ion channel regulation, vital for our cellular biology research.
Q&As
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What is the primary application of the Mouse Anti-SLC26A4 Recombinant Antibody in research?
A: The Mouse Anti-SLC26A4 Recombinant Antibody is predominantly used in the study of ion transport and associated disorders, such as Pendred syndrome and non-syndromic hearing loss. Its applications in Western blotting, immunofluorescence, and functional studies enable researchers to explore the expression and function of the SLC26A4 protein across various tissues.
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How does targeting SLC26A4 contribute to understanding genetic diseases?
A: SLC26A4, involved in chloride and iodide transport, is crucial for normal hearing and thyroid function. Mutations in this gene are linked to Pendred syndrome, characterized by goiter and hearing loss. By targeting SLC26A4, the antibody aids in understanding the pathophysiology of these conditions, potentially paving the way for therapeutic interventions.
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In which research areas is the SLC26A4 antibody particularly useful?
A: This antibody is notably useful in genetic research related to hereditary deafness, endocrine studies concerning thyroid hormone regulation, and broader cellular transport mechanisms. These applications facilitate detailed investigations into how defects in anion transport can lead to systemic disorders.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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