Recombinant Anti-Human ADCYAP1R1 Antibody (Non-glycosylated) (CAT#: Gly-193LC)
This product is a non-glycosylated human monoclonal antibody. The antibody has increased efficacy as well as decreased side effect, it specifically binds to human Pac1 and can be potentially used in the treatment of migraine.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30739/1735_E10_1_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/30739/1735_E10_1_selected.jpg
Figure 2 High expression in cerebral cortex
(Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_B_7_5.jpg
(Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_B_7_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_A_9_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_A_9_3.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_A_9_5.jpg
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_A_9_5.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49877/113058_A_4_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078549-ADCYAP1R1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078549-ADCYAP1R1
Glyco-engineering
- Activity
- Increased efficacy and/or decreased side effects
Specifications
- Target
- Pac1 (Pituitary adenylate cyclase-activating polypeptide type I receptor)
- Host Species
- Human
- Derivation
- XENOMOUSE
- Type
- Human antibody
- Specificity
- Human
- Antibody Isotype
- IgG
- Clone
- 39B
- Applications
- ELISA
Target
- Alternative Names
- ADCYAP1R1; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; PAC1; PAC1R; PACAPR; PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP-R1; PACAP receptor 1; PACAP type I receptor; pituitary adenylate cyc
- Related Disease
- Migraine
- Gene ID
- 117
- UniProt ID
- A0A090N8F8
Downloads
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IgG Antibody Products
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3850z | Mouse Anti-ADCYAP1R1 Recombinant Antibody (clone 15H5) | WB, IP, ELISA | Mouse IgG1, κ |
| HPAB-0431-YJ | Human Anti-ADCYAP1R1 Recombinant Antibody (HPAB-0431-YJ) | Block, FuncS | Human IgG2, κ |
| HPAB-0432-YJ | Human Anti-ADCYAP1R1 Recombinant Antibody (HPAB-0432-YJ) | Block, FuncS | Human IgG2, κ |
| HPAB-0437YY | Human Anti-ADCYAP1R1 Recombinant Antibody (HPAB-0437YY) | Inhib, FC | Humanized IgG |
| VS-0923-FY253 | Recombinant Human Anti-ADCYAP1R1 Antibody (clone Zelminemab) | Inhib | Human IgG1, kappa |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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