Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated)

Name: Recombinant Anti-Human CD19 Antibody (Fc glycosylation/Non fucosylated)
SKU: Gly-141LC-1
Rating: 5 (1 reviews)

CAT#: Gly-141LC-1

This product is a non-fucosylated humanized monoclonal antibody. The antibody with enhanced ADCC specficfically binds to human CD19 and can be potentially used in the treatment of graft-versus-host disease and post-transplantation lymphoproliferative disorder.

Gene Expression

Normal Tissue Figure 1 Colon

Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_7_3.jpg

Normal Tissue Figure 2 Testis

Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_5_6.jpg

Normal Tissue Figure 3 Appendix

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_2_2.jpg

Normal Tissue Figure 4 Lymph node

Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16110/36120_A_9_8.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177455-CD19

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Glyco-engineering

Glycosylation site
Asn297 in Fc region

Glycosylation Type
N-glycosylation

Activity
Enhanced ADCC

Specifications

Target
CD19 (Cluster of differentiation-19)

Host Species
Human

Type
Humanized antibody

Specificity
Human

Antibody Isotype
IgG

Clone
3649-aFuc

Applications
ELISA

Target

Alternative Names
CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4;

Related Disease
Graft-versus-host disease and post-transplantation lymphoproliferative disorder

Gene ID
930

UniProt ID
P15391

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Related Diseases

Primary Immunodeficiency

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - Gly-141LC-1.pdf

MSDS

MSDS - Gly-141LC-1.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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CAT
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