Recombinant Anti-Human CD22 Antibody (Fab glycosylation) (CAT#: Gly-001LC)
This product is a mouse monoclonal antibody with N-glycosylation sites in FR1 of VK. The glycan in variable region does not affect the immunoreactivity and can be used for conjugating therapeutic or diagnostic agents. Antibody LL2 specifically binds human CD22 and can be potentially used in the treatment of B-cell lymphoma.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_A_7_8.jpg
Figure 2 Spleen
(Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg
(Cells in red pulp
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2418/6101_B_7_4.jpg
Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
Figure 3 RNA cell line category: Cell line enhanced (Daudi, REH, U-698, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000012124-CD22
Glyco-engineering
- Glycosylation site
- FR1 of VK
- Glycosylation Type
- N-glycosylation
- Activity
- Do not affect the immunoreactivity and can be used for conjugating therapeutic or diagnostic agents
Specifications
- Target
- CD22 (Cluster of differentiation-22)
- Host Species
- Mouse
- Type
- Mouse antibody
- Specificity
- Human
- Antibody Isotype
- IgG2a
- Clone
- LL2
- Applications
- ELISA, FC
Target
- Alternative Names
- CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2
- Related Disease
- B-cell lymphoma
- Gene ID
- 933
- UniProt ID
- P20273
Downloads
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1248z | Mouse IgG1, kappa Anti-CD22 Recombinant Antibody (MOB-1248z) | IF, FC | Mouse IgG1, κ |
| VS3-XY236 | Mouse Anti-CD22 Recombinant Antibody (clone 2H1C4) | ELISA, WB, IHC, FC, ICC | Mouse IgG1 |
| VS3-XY237 | Mouse Anti-CD22 Recombinant Antibody, FITC (clone 4ABU59) | FC, IF | Mouse IgG1 |
| VS3-XY238 | Mouse Anti-CD22 Recombinant Antibody, PE (clone 4ABU59) | FC, IF | Mouse IgG1 |
| VS3-XY239 | Mouse Anti-CD22 Recombinant Antibody (clone 4ABU59) | FC, IF | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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