Recombinant Anti-Human EPHA3 Antibody (Fc glycosylation/Low fucosylated)
CAT#: Gly-101LC
This product is a low fucosylated human antibody with enhanced ADCC. The antibody specifically binding to EphA3 and can be potentially used in the treatment of multiple myeloma.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, plasma membrane, cytosol & actin filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69390/1819_G10_18_cr59f32f9e0f828_selected.jpg
Normal Tissue
Figure 2 IHC staining of human parathyroid gland
Immunohistochemical staining of human parathyroid gland shows cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_B_9_5.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_5_6.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10462/24404_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enriched (AF22)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000044524-EPHA3
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Glyco-engineering
- Glycosylation site
- Fc region
- Glycosylation Type
- N-glycosylation
- Activity
- Enhanced ADCC
Specifications
- Target
- EphA3 (Ephrin type-A receptor 3)
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Antibody Isotype
- IgG1, κ
- Expression Host
- CHOK1SV
- Applications
- ELISA
Target
- Alternative Names
- EPHA3; EPH receptor A3; EK4; ETK; HEK; ETK1; HEK4; TYRO4; ephrin type-A receptor 3; EPH-like kinase 4; human embryo kinase 1; eph-like tyrosine kinase 1; TYRO4 protein tyrosine kinase; tyrosine-protein kinase receptor ETK1
- Related Disease
- Multiple myeloma
- Gene ID
- 2042
- UniProt ID
- P29320
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Datasheet
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COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC66 | Anti-EPHA3 Antibody Prodrug, Protease Activated (VS-1025-YC66) | ISZ, Cyt, FuncS |
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